Searchable abstracts of presentations at key conferences in endocrinology

ea0034p406 | Thyroid | SFEBES2014

Hypoxic incubation favours the development and growth of primary human parathyroid adenoma cells

Lines Kate E , Stevenson Mark , Mihai Radu , Grigorieva Irina V , Baban Dilair , Gaynor Katherine U , Jeyabalan Jeshmi , Javid Mahsa , Thakker Rajesh V

Hypoxia is a primary stimulus for angiogenesis, which is important for tumour proliferation and survival. The effects of hypoxia on parathyroid tumour cells, which may be important for parathyroid autotransplantation in patients, are however, not known. We therefore assessed the effects of hypoxia on gene expression in parathyroid adenoma cells from patients with primary hyperparathyoridism. Cell suspensions from human parathyroid adenomas (n=5) were cultured and afte...